Jan 16 / Warren Lucas

The Neuroscience of Exercise: Enhancing Mental and Cognitive Health

Is all the intelligence in the human body in the brain?

In the ever-evolving landscape of healthcare, the role of exercise in promoting well-being extends far beyond its physical benefits. Emerging research in neuroscience has shed light on the intricate connections between physical activity and the cognitive and mental health of individuals (1–3). This article aims to provide a comprehensive understanding of the neurobiological mechanisms underlying the cognitive and mental health benefits of exercise, written in a manner that is accessible to the average reader interested in the field of neuroscience and neuropsychology. 


The human brain is a remarkably complex and dynamic organ, constantly adapting to the demands placed upon it. Exercise, as a form of physical activity, has been found to elicit a wide range of neurobiological changes that contribute to enhanced cognitive function and improved mental health. One of the key mechanisms underlying these benefits is the increased synthesis and release of neurotransmitters and neurotrophic factors, which are essential for neurogenesis, angiogenesis, and neuroplasticity (3). Exercise has been shown to stimulate the production of growth factors, such as brain-derived neurotrophic factor, which are crucial for the development and growth of neurons, as well as the formation of new blood vessels (angiogenesis) that improve cerebral blood flow and oxygenation (1). 


Additionally, exercise is associated with the release of anti-inflammatory cytokines, which help to reduce neuroinflammation, and the enhancement of mitochondrial biogenesis and antioxidant enzyme activity, which mitigate oxidative stress – both of which are known to contribute to cognitive decline and mental health issues. Another important mechanism by which exercise can enhance cognitive and mental health is through the modulation of neurotransmitter systems. Exercise has been found to increase the release of neurotransmitters such as dopamine and serotonin, which play a crucial role in regulating mood, motivation, and cognitive processes such as attention, learning, and memory (1).

The cognitive benefits of exercise are not limited to immediate effects but can also have long-term implications. Research has shown that regular physical activity can lead to structural and functional changes in the brain, including increased brain volume, dendritic spine growth, and neurogenesis, particularly in the hippocampus and other brain regions associated with memory and learning.

The implications of these neurobiological mechanisms are far-reaching, as they suggest that exercise can be a powerful tool for the prevention and management of a wide range of mental health conditions, such as depression, anxiety, and cognitive impairment. Furthermore, the cognitive benefits of exercise have been observed across various age groups, from children to older adults, highlighting the importance of incorporating physical activity into our daily lives at all stages of life.

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References:
1. Chen C, Nakagawa S. Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms. Vol. 86, Ageing Research Reviews. Elsevier Ireland Ltd; 2023.
2. Solis-Urra P, Fernandez-Gamez B, Liu-Ambrose T, Erickson KI, Ortega FB, Esteban-Cornejo I. Exercise as medicine for the brain: moving towards precise and personalised recommendations. Br J Sports Med [Internet]. 2024 Jul 1;58(13):693. Available from: http://bjsm.bmj.com/content/58/13/693.abstract
3. Matta Mello Portugal E, Cevada T, Sobral Monteiro-Junior R, Teixeira Guimarães T, da Cruz Rubini E, Lattari E, et al. Neuroscience of Exercise: From Neurobiology Mechanisms to Mental Health. Neuropsychobiology [Internet]. 2013 Jun 15;68(1):1–14. Available from: https://doi.org/10.1159/000350946

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References

  1. Cornwall N, Swaithes L, Woodcock C, Healey EL, Hider SL. Implementation of physical activity interventions for people with inflammatory arthritis: an overview and future recommendations. Vol. 7, Rheumatology Advances in Practice. Oxford University Press; 2023. 
  2. Birdee GS, Ayala SG, Wallston KA. Cross-sectional analysis of health-related quality of life and elements of yoga practice. BMC Complement Altern Med. 2017 Jan 31;17(1). 
  3. Xu S, Baker JS, Ren F. The positive role of tai chi in responding to the covid-19 pandemic. Int J Environ Res Public Health. 2021 Jul 2;18(14). 
  4. Strickland JC, Smith MA. The anxiolytic effects of resistance exercise. Vol. 5, Frontiers in Psychology. Frontiers Research Foundation; 2014.
  5. Xie Y, Wu Z, Sun L, Zhou L, Wang G, Xiao L, et al. The Effects and Mechanisms of Exercise on the Treatment of Depression. Vol. 12, Frontiers in Psychiatry. Frontiers Media S.A.; 2021. 
  6. Herbert C, Meixner F, Wiebking C, Gilg V. Regular Physical Activity, Short-Term Exercise, Mental Health, and Well-Being Among University Students: The Results of an Online and a Laboratory Study. Front Psychol. 2020 May 26;11. 
  7. Arsović N, Đurović R, Rakočević R. Influence of Physical and Sports Activity on Mental Health. Facta Universitatis, Series: Physical Education and Sport. 2020 Jan 16;559. 
  8. Shaphe MA, Chahal A. Relation of Physical Activity with the Depression: A Short Review. J Lifestyle Med. 2020 Jan 31;10(1):1–6. 
  9. Kondo M. Molecular Mechanisms of Exercise-induced Hippocampal Neurogenesis and Antidepressant Effects. JMA J. 2023 Apr 20;6(2):114–9. 
  10. Archer T. Physical Exercise and its Impact on Psychology. Clin Exp Psychol. 2016;02(02). 
  11. López-Torres Hidalgo J, Sotos JR, Salmerón LA, Gras CB, Rosa MC, Escobar Rabadán F, et al. Effectiveness of physical exercise in older adults with mild to moderate depression. Ann Fam Med. 2021 Jul 1;19(4):302–9. 
  12. Brown DMY, Bray SR. Acute effects of continuous and high-intensity interval exercise on executive function. J Appl Biobehav Res. 2018 Sep 1;23(3). 13.      Wheeler AJ, Roennfeldt H, Slattery M, Krinks R, Stewart V. Codesigned recommendations for increasing engagement in structured physical activity for people with serious mental health problems in Australia. Health Soc Care Community. 2018 Nov 1;26(6):860–70.
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